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SABE belle BIOMALIFE® PEABIOMA enteric coated tablets, 30 ST

Product information "SABE belle BIOMALIFE® PEABIOMA enteric coated tablets"
SABE belle BIOMALIFE® PEABIOMA tablets are a dietary supplement based on palmitoylethanolamide. Each tablet contains 200 mg of micronised palmitoylethanolamide with modified active ingredient release.

The intestinal barrier

  • The intestinal barrier is the largest interface and contact surface between our body and the outside world. It acts as an extremely precise, active filter and protective mechanism, distinguishing between nutrients and beneficial substances on the one hand, and potentially harmful antigens and microorganisms on the other. At the heart of the intestinal barrier is the epithelium. This consists of intestinal cells that are firmly bound together by tight junctions, and the protective mucus layer that covers and protects these cells. 
  • Various factors can damage the intestinal barrier: the protective mucus layer becomes thinner and, in places, is absent or disrupted; the tight junctions open up, creating gaps between the cells (leaky gut syndrome). 
  • These gaps allow antigens, toxins and bacteria to penetrate the intestinal barrier and enter the gut-associated lymphoid tissue (GALT). The GALT reacts to these foreign substances and activates immune cells, which secrete pro-inflammatory substances. This inflammation of the gut exacerbates the existing disruption of the gut barrier, creating a vicious circle.
Active ingredients

  • Palmitoylethanolamide ( PEA) is a substance similar to the endocannabinoids produced by the body, which possess anti-inflammatory and pain-relieving properties. PEA acts as a biological modulator in controlling tissue hyperreactivity. In fact, it inhibits the release of chemical inflammatory mediators by mast cells. Endogenous PEA levels are reduced in chronic intestinal inflammation. Recent findings show that PEA indirectly activates the CB2 receptors for endocannabinoids, resulting in pain relief.
  • Vitamin B2 (or riboflavin) is essential for maintaining healthy mucous membranes – not only in the gut, but throughout the body. Several bacterial families are involved in its biosynthesis: Fusobacteria, Proteobacteria, Firmicutes, Bacteroides and Prevotella. A vitamin B2 deficiency in the gut can lead to abnormal growth of intestinal cells, impaired cell division (mitosis) and an accumulation of aneuploid cells in the large intestine (cells with deviations from the normal chromosome count). At the macroscopic level, a deficiency of this vitamin is recognisable by: glossitis (inflammation of the tongue), cheilosis (a skin condition of the lips characterised by flaking and dryness), redness, a burning sensation and itching of the eyes.
Indications

  • ​​RDS-D and RDS-M – Irritable Bowel Syndrome (diarrhoea, and diarrhoea and constipation simultaneously)
  • IBD – Crohn’s disease and ulcerative colitis
  • Diverticular disease
  • Coeliac disease
  • Idiopathic diarrhoea (of unknown cause)
  • Acute diarrhoea (with pain)
  • Traveller’s diarrhoea (with pain)
  • Diarrhoea following a course of antibiotics
  • Abnormal sensations following a colonoscopy (with pain)
  • Epigastric pain syndrome
Notes

  • Gluten-free
  • Naturally lactose-free
  • No sweeteners
  • No added sugar
  • No preservatives
• E. Salvo-Romero, C. Alonso-Cotoner and C. Pardo-Camacho, ‘The intestinal barrier function and its involvement in digestive disease’, Rev Esp Enferm Dig, vol. 107, no. 11, pp. 686–696, 2015. • G. Sander, A. Cummins, T. Henshall et al., ‘Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins’, FEBS Lett, vol. 579, pp. 4851–4855, 2005. • S. Zeissig, N. Bürgel, D. Günzel et al., ‘Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease’, Gut, vol. 56, pp. 61–72, 2007. • C. Martínez, B. Lobo, M. Pigrau et al., ‘Diarrhoea-predominant irritable bowel syndrome: An organic disorder with structural abnormalities in the jejunal epithelial barrier’, Gut, vol. 62, pp. 1160–1168, 2013. • M. Ventura, L. Polimeno, A. Amoruso et al., ‘Intestinal permeability in patients with adverse reactions to food’, Dig Liver Dis, vol. 38, pp. 732–736, 2006. • F. Borrelli, B. Romano, S. Petrosino et al., ‘Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent’, Br J Pharmacol, vol. 172, no. 1, pp. 142–58, 2015. • G. Esposito, E. Capoccia, F. Turco et al., ‘Palmitoylethanolamide improves colon inflammation through an enteric glia/Toll-like receptor 4-dependent PPAR-alpha activation,’ Gut, vol. 63, no. 8, pp. 1300–1312, 2014. • S. Petrosino and V. Di Marzo, ‘The pharmacology of palmitoylethanolamide and initial data on the therapeutic efficacy of some of its new formulations,’ Br J Pharmacol, vol. 174, no. 11, pp. 1349–1365, 2017.


Dosage form
Enteric-coated tablets

Directions for use
  • Take 1 to 2 tablets daily, preferably with a meal, with a little water.
  • Notes: Consult a doctor before taking this product during pregnancy or whilst breastfeeding. The tablets must not be broken or crushed; they must be swallowed whole.
Ingredients
  • Ingredients: FILLERS: MICROCRYSTALLINE CELLULOSE, DICALCIUM PHOSPHATE; PALMITOYLETHANOLAMIDE, STABILISER: HYDROXYPROPYL CELLULOSE; COATING AGENTS: ETHYL CELLULOSE, FATTY ACIDS, SODIUM ALGINATE, AMMONIUM HYDROXIDE, POLYVINYL ALCOHOL, POLYETHYLENE GLYCOL, TALC; MEDIUM-CHAIN TRIGLYCERIDES, COLOURING AGENT: CALCIUM CARBONATE; ANTI-CAKING AGENTS: SILICA, MAGNESIUM SALTS OF FATTY ACIDS; CROSSLINKED SODIUM CARBOXYMETHYL CELLULOSE, VITAMIN B2 (RIBOFLAVIN).
  • Composition per daily dose (2 tablets) %NRV*: Palmitoylethanolamide 400 mg, vitamin B2 (riboflavin) ​​2.8 mg (200% NRV*) ​.* NRV = Nutrient Reference Values for the daily intake of vitamins and minerals (adults) in accordance with Regulation (EU) No 1169/2011.
Gluten-free: Yes
Lactose-free: Yes
Piece: 30
Vegetarian: Yes
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