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SABE belle BIOMALIFE® PEABIOMA enteric coated tablets, 30 ST

Product information "SABE belle BIOMALIFE® PEABIOMA enteric coated tablets"
SABE belle BIOMALIFE® PEABIOMA tablets are a food supplement based on palmitoylethanolamide. Each tablet contains 200 mg of micronised palmitoylethanolamide with modified release of the active ingredient.

The intestinal barrier

  • The intestinal barrier is the largest interface and contact surface between our organism and the outside world. It functions as an extremely precise, active filter and protective mechanism and distinguishes nutrients and beneficial substances from potentially harmful antigens and microorganisms. The epithelium is the centrepiece of the intestinal barrier. This consists of the intestinal cells, which are firmly connected to each other by tight junctions, and the protective mucus layer that covers and protects these cells.
  • Various factors can damage the intestinal barrier: The protective mucus layer becomes thinner and is absent or interrupted in places; the tight junctions open up and spaces are created between the cells (leaky gut syndrome).
  • These gaps allow antigens, toxins and bacteria to penetrate the intestinal barrier and enter the gut-associated immune system (GALT). The GALT reacts to these foreign bodies and activates immune cells that secrete pro-inflammatory substances. This inflammation of the intestine exacerbates the already existing disruption of the intestinal barrier, as if in a vicious circle.
Active ingredients

  • Palmitoylethanolamide (PEA) is an analogue of the endocannabinoids produced by the body, which have anti-inflammatory and analgesic properties. PEA acts as a biological modulator in the control of tissue hyperreactivity. In fact, it inhibits the release of chemical inflammatory mediators by mast cells, and endogenous PEA levels are reduced in chronic intestinal inflammation. Recent evidence shows that PEA indirectly activates CB2 receptors for endocannabinoids, resulting in pain relief.
  • Vitamin B2 (or riboflavin) is essential for maintaining healthy mucous membranes - not just in the gut, but throughout the body. Several families of bacteria are involved in its biosynthesis: Fusobacteria, Proteobacteria, Firmicutes, Bacteroides, Prevotella. A vitamin B2 deficiency in the intestine can lead to unfavourable growth of intestinal cells, impaired cell division (mitosis) and an accumulation of aneuploid cells in the large intestine (cells with deviations from the normal number of chromosomes). On a macroscopic level, a deficiency of this vitamin can be recognised by Glossitis (inflammation of the tongue), cheilosis (skin disease of the lips, characterised by scaling and dryness), redness, burning and itching of the eyes.
Areas of application

  • IBS-D and IBS-M - irritable bowel syndrome (diarrhoea and diarrhoea and constipation at the same time)
  • CED - Crohn's disease and ulcerative colitis
  • Diverticular disease
  • Coeliac disease
  • Idiopathic diarrhoea (with unknown cause)
  • Acute diarrhoea (with pain)
  • Traveller's diarrhoea (with pain)
  • Diarrhoea after antibiotic therapy
  • Discomfort after a colonoscopy (with pain)
  • Epigastric pain syndrome
Indications

  • Gluten-free
  • Naturally lactose-free
  • Without sweeteners
  • No added sugar
  • No preservatives
- E. Salvo-Romero, C. Alonso-Cotoner e C. Pardo-Camacho, "The intestinal barrier function and its involvement in digestive disease," Rev Esp Enferm Dig, vol. 107, n. 11, pp. 686-696, 2015. - G. Sander, A. Cummins, T. Henshall e al, "Rapid disruption of intestinal barrier function by gliadin involves altered expression of apical junctional proteins," FEBS Lett, vol. 579, pp. 4851-4855, 2005. - S. Zeissig, N. Bürgel, D. Günzel e al, "Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease," Gut, vol. 56, pp. 61-72, 2007. - C. Martínez, B. Lobo, M. Pigrau e al, "Diarrhoea-predominant irritable bowel syndrome: An organic disorder with structural abnormalities in the jejunal epithelial barrier," Gut, vol. 62, pp. 1160-1168, 2013. - M. Ventura, L. Polimeno, A. Amoruso e al, "Intestinal permeability in patients with adverse reactions to food," Dig Liver Dis, vol. 38, pp. 732-736, 2006. - F. Borrelli, B. Romano, S. Petrosino e al, "Palmitoylethanolamide, a naturally occurring lipid, is an orally effective intestinal anti-inflammatory agent," Br J Pharmacol, vol. 172, n. 1, pp. 142-58, 2015. - G. Esposito, E. Capoccia, F. Turco e al, "Palmitoylethanolamide improves colon inflammation through an enteric glia/toll like receptor 4-dependent PPAR-alpha activation," Gut, vol. 63, n. 8, pp. 1300-1312, 2014. - S. Petrosino e V. Di Marzo , "The pharmacology of palmitoyletathanolamide and first data on the therapeutic efficacy of some of its new formulations," Br J Pharmacol, vol. 174, n. 11, pp. 1349-1365, 2017.


Dosage form
Gastro-resistant tablets

Administration
  • Take 1 to 2 tablets daily, preferably during a meal, with a little water.
  • Advice: Consult a doctor before taking during pregnancy and while breastfeeding. The tablets must not be crushed or ground but must be taken whole.
Ingredients
  • Ingredients: FILLERS: MICROCRYSTALLINE CELLULOSE, DICALCIUM PHOSPHATE; PALMITOYLETHANOLAMIDE, STABILISER: HYDROXYPROPYL CELLULOSE; GLAZING AGENTS: ETHYL CELLULOSE, FATTY ACIDS, SODIUM ALGINATE, AMMONIUM HYDROXIDE, POLYVINYL ALCOHOL, POLYETHYLENE GLYCOL, TALC; MEDIUM-CHAIN TRIGLYCERIDES, COLOURING AGENT: CALCIUM CARBONATE; SEPARATING AGENTS: SILICON DIOXIDE, MAGNESIUM SALTS OF FATTY ACIDS; CROSS-LINKED SODIUM CARBOXYMETHYLCELLULOSE, VITAMIN B2 (RIBOFLAVIN).
  • Composition per daily dose (2 tablets)%NRV*: Palmitoylethanolamide 400 mg, vitamin B2 (riboflavin) 2.8 mg (200% NRV*) .* NRV = reference amounts for the daily intake of vitamins and minerals (adults) according to Regulation (EU) No. 1169/2011.
Glutenfrei: Ja
Laktosefrei: Ja
Vegetarier: Ja
Stück: 30
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