Ostenil® 20mg/2ml prefilled syringe, 1 ST

OSTENIL® Sodium hyaluronate from fermentation 1.0%. Viscoelastic solution for injection into the joint space. Sterile due to moist heat.

Indications

• Pain and restricted mobility in degenerative and traumatic changes of the knee joint and other synovial joints.

Properties and mode of action

• Synovial fluid, which is viscoelastic due to its hyaluronic acid content, is found in all synovial joints, especially in the large weight-bearing joints, where its lubricating and shock-absorbing properties ensure normal, pain-free movement. It is also responsible for supplying the joint cartilage with nutrients. In degenerative joint diseases, such as osteoarthritis, the viscoelasticity of synovial fluid is significantly impaired, which reduces its lubricating and shock-absorbing effect.
• As a result, the mechanical load on the joint and the degradation of the joint cartilage increase to such an extent that pain and limited mobility occur in the affected joint. Improving the quality of the synovial fluid by intra-articular administration of high-purity hyaluronic acid can improve the viscoelastic properties of the synovial fluid. This improves its lubricating and shock-absorbing effect and reduces the mechanical overloading of the joint. The result is usually a reduction in pain and an improvement in joint mobility, whichcan last for several months aftera treatment cycle of five intra-articular injections.

Dosage form

injection

How to use

Inject OSTENIL® into the affected joint a total of 3-5 times at weekly intervals. Several joints can be treated at the same time. Depending on the severity of the joint disease, the effect of treatment with five injections can last for more than six months. Repeated treatment cycles are possible if necessary. If a joint effusion is present, it is advisable to puncture the effusion, immobilise the joint and apply an ice pack and/or administer corticosteroids intra-articularly. Two to three days later, treatment with OSTENIL® is started.

As long as the sterile packaging has not been opened, the contents and surface of the OSTENIL® prefilled syringe are sterile. The prefilled syringe is removed from the sterile packaging, the cap is unscrewed from the Luer lock connection, a suitable cannula (e.g. 19 to 21 G) is attached and this is locked in place by turning it slightly. Before the injection, any air bubble is removed from the syringe.

Ingredients

1 ml isotonic solution contains 10.0 mg sodium hyaluronate as well as sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate and water for injection.