IALURIL® Prefill prefilled syringe 50 ml, 1 ST

IALURIL® Prefill is indicated for the restoration of the glycosaminoglycan (GAG) layers of the vesical urothelium in cases where the loss of these layers may cause frequent and recurrent symptoms (such as cystitis, etc.)

The urothelium is lined with a layer of polyanionic molecules, consisting predominantly of glycosaminoglycans (GAG), a class of amino sugars that form an impenetrable and neutralising protective barrier against the toxic and irritating substances present in the urine (such as bacteria, microcrystals, proteins, ionic and non-ionic residues, etc.) and prevent their systemic reabsorption.

Of the GAGs that form this protective barrier, chondroitin sulphate and hyaluronic acid play a central role in the barrier’s function.

Qualitative and quantitative fluctuations in these two GAGs at various levels inactivate the barrier effect, thereby causing a range of conditions that may predispose to the occurrence of cystitis of various types (e.g. interstitial cystitis, recurrent cystitis caused by infections, cystitis induced by cancer treatment agents, radiation-induced cystitis, and traumatic cystitis).

IALURIL® Prefill, a balanced combination of sodium hyaluronate, chondroitin sulphate and calcium chloride, can be functionally integrated into the barrier thanks to the action of the calcium chloride, thereby restoring its protective function.

Indications

IALURIL® Prefill is indicated for the restoration of the glycosaminoglycan (GAG) layers of the vesical urothelium in cases where their loss may cause frequent and recurrent symptoms (such as cystitis of various aetiologies).

IALURIL® Prefill is also indicated in cases where the loss of the glycosaminoglycan (GAG) layers is associated with forms of chronic inflammation in which the composition and integrity of these layers are compromised.

Dosage form

Pre-filled syringe, 50 ml

Method of administration

It is recommended that the contents of one pre-filled syringe be instilled according to the following schedule:

• 1 instillation per week during the first month.
• 1 instillation every two weeks during the second month.
• In the following months, 1 instillation per month is recommended until symptoms have stabilised and the patient is symptom-free.

Notes: Administration must only be carried out by qualified doctors.

Ingredients

Composition: Each 50 ml pre-filled IALURIL® Prefill syringe contains: water, calcium chloride, sodium hyaluronate, sodium chondroitin sulphate.