GO-ON® prefilled syringe 2.5 ml, sterile, 1 ST

GO-ON® prefilled syringes contain a sterile, pyrogen-free sodium hyaluronate solution. GO-ON is indicated as a viscoelastic supplementation of the synovial fluid in the knee.

Sodium hyaluronate is a natural, high molecular weight polysaccharide composed of a linear chain of disaccharide building blocks consisting of sodium glucuronate and N-acetylglucosamine. Sodium hyaluronate is found in many tissues of the human organism and is the main component of synovial fluid, in which it is present in high concentrations. It plays an important role as a synovial lubricant in harmonising the physical and mechanical interactions between adjacent tissues. As a viscoelastic support material, it also maintains the distance between the tissues. Sodium hyaluronate preparations can have different molecular weights, but have the same chemical structure. GO-ON® is a 1% sodium hyaluronate solution obtained from Streptococcus equi by fermentation processes and subsequent purification.

Fields of application

GO-ON is indicated as a viscoelastic supplementation of the synovial fluid in the knee. Viscosupplementation is recommended for patients of normal weight or moderately overweight with symptomatic mild to moderate knee OA whose condition cannot be sufficiently improved by non-pharmacological treatment and analgesics/NSAIDs or who cannot take analgesics/NSAIDs. The product has a lubricating and mechanically supportive effect and is suitable for treating the symptoms of osteoarthritis.

Properties and mode of action

Synovial fluid, which is viscoelastic due to its hyaluronic acid content, is found in all synovial joints, especially in the large joints, which are subject to considerable stress due to body weight. Here, synovial fluid acts as a joint lubricant and shock absorber, thus ensuring normal, pain-free joint movements. Synovial fluid also supplies the joint cartilage with nutrients. Degenerative joint diseases such as arthrosis are associated with a significant reduction in the viscosity of the synovial fluid, which leads to an impairment of its lubricating and shock-absorbing function. As a result, the mechanical stress on the joint and the loss of articular cartilage tissue increase to such an extent that pain and functional limitations occur in the affected joints. It has been shown that an improvement in the quality of the synovial fluid caused by the intra-articular injection of sodium hyaluronate preparations also improves its viscoelastic properties. This promotes its function as a lubricant and shock absorber, which leads to a reduction in mechanical joint stress. This results in pain relief and improved joint mobility. This effect can last for more than six months after a treatment cycle of five intra-articular injections.

Dosage form

Prefilled syringe, sterile

How to use

• GO-ON should be injected into the affected joint a total of 5 times at weekly intervals. Depending on the severity of the joint disease, the effect of a course of five treatments can last for 6 months.
• The treatment cycles can be repeated if necessary. If there is an effusion in a joint, it is recommended to puncture it, immobilise the joint, apply an ice pack and/or administer corticosteroids by intra-articular injection.
• Treatment with GO-ON® can be repeated 2-3 days later. Take the syringe out of the blister, remove the rubber stopper, attach a suitable sterilised needle (e.g. 19 or 21 G) and fix it in place by twisting it slightly. When attaching the needle and removing the needle guard, make sure that you do not overtighten it or lever it too hard. Press excess air out of the syringe before injecting. GO-ON should be administered separately and should not be mixed with other substances before injection.
• Notes: This product may only be used by physicians. In particular, the doctor should be trained as an orthopaedist, rheumatologist or physiotherapist.

Ingredients

1 GO-ON® prefilled syringe contains 2.5 ml of a 1% sodium hyaluronate solution as well as sodium chloride, sodium monohydrogen phosphate, sodium dihydrogen phosphate and water for injection.